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What is AB-CHMINACA?

AB-CHMINACA is a synthetic cannabinoid chemically designed to activate the same receptors as THC (tetrahydrocannabinol), the active compound in natural cannabis. However, it interacts with those receptors much more strongly, leading to intense and sometimes dangerous effects.

• IUPAC name: N-[(1S)-1-(aminocarbonyl)-2-methylpropyl]-1-(cyclohexylmethyl)-1H-indazole-3-carboxamide

• Molecular formula: C20H28N4O2

• Molecular weight: ~356.46 g/mol

• Common form: Off-white to yellow crystalline powder

The compound belongs to the indazole-3-carboxamide family of synthetic cannabinoids, known for their strong activity at CB1 and CB2 receptors.

Chemical Structure and Classification

AB-CHMINACA contains:

• A cyclohexylmethyl group: increases lipophilicity (fat-solubility), helping the molecule pass through the blood-brain barrier.

• An indazole core: common in many synthetic cannabinoids.

• A valinate (amino acid-derived) side chain: this design enhances receptor binding.

Its structure is similar to that of other dangerous synthetic cannabinoids like AB-FUBINACA, which has been linked to mass overdoses.

Mechanism of Action

AB-CHMINACA acts as a full agonist at the CB1 and CB2 cannabinoid receptors:

• CB1 receptors are mainly located in the central nervous system and mediate most psychoactive effects.

• CB2 receptors are mostly found in the immune system and are linked to inflammatory responses.

Unlike THC, which is a partial agonist at these receptors, AB-CHMINACA binds more strongly and more completely, resulting in amplified effects and a greater risk of overdose.

Effects of CB1 receptor overstimulation:

• Euphoria and altered consciousness

• Panic, paranoia, hallucinations

• Heart rhythm disturbances

• Loss of motor control

Because of the full agonist activity and high potency, even very small doses of AB-CHMINACA can cause serious health effects.

Buy AB-CHMINACA crystal also 1-(cyclohexylmethyl)-1H-indazole-3- carboxamide. (AB-CHMINACA). is an indazole-based synthetic cannabinoid. It is a potent agonist of the CB1 receptor (Ki = 0.78 nM) and CB2 receptor (Ki = 0.45 nM) and fully substitutes for ?9-THC in rat discrimination studies, while being 16x more potent.

it contains a valine amino acid amide residue as part of its structure, where older cannabinoids contained a naphthyl or adamantane residue.

Formula:
C20H28N4O2

ChemSpider ID:
30646774

IUPAC name
N-[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]-1-(cyclohexylmethyl)indazole-3-carboxamide

An Analytical Reference Standard
Item No.
28236

Purity:
?98%

Formulation:
A crystalline solid
ADB-CHMINACA (MAB-CHMINACA)
is a new synthetic cannabinoid with high potency and many reported adverse events and fatalities. The drug is currently scheduled in several countries in Europe and the USA.

Analyse
Analyse method developed to confirm ADB-CHMINACA intake for clinical and forensic programs. For many synthetic cannabinoids, parent compound is not detectable in biological samples after intake, making the detection of metabolites the only way to prove consumption. Therefore, detection of ADB-CHMINACA metabolites in biological specimens is critical.

Part Description
LP262538-4 AB-CHMINACA butanoate
AB-CHMINACA hydroxycyclohexyl and AB-CHMINACA butanoate are metabolites of AB-CHMINACA (N-[1-amino-3-methyl-oxobutan-2-yl]-1-[cyclohexylmethyl]-1H-indazole-3-carboxamide), an indazole-based synthetic cannabinoid that shows high affinity for cannabinoid CB1 and CB2 receptors.

Synthetic cannabinoids interact with the same brain receptors as THC (the active drug present in marijuana) and have been demonstrated to produce similar effects. The drug is typically sprayed on botanical material and smoked, although it can be ingested in liquid or also powder form. Products containing this drug are sold under a wide variety of names including (but not limited to) Spice, Potpourri, Smoke, K2, Zombie, Kush, and Cloud 10.