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Buy 5F-PB22 Crystal is a designer drug which acts as a cannabinoid agonist. The structure of 5F-PB-22 appears to have been designed with an understanding of structure–activity relationships within the indole class of cannabinoids.

5-fluoro PB-22 (Item No. 14095) is an analytical reference material that is structurally categorized as a synthetic cannabinoid (CB). It is a full agonist of human CB1 and CB2 receptors (pEC50s = 8.55 and 7.97, respectively).1,2 5-fluoro PB-22 potently and dose-dependently induces hypothermia and reduces heart rate in rats, mimicking the in vivo effects of ?9-THC (Item Nos. 12068 | ISO60157).1 This product is intended for research and forensic applications.

5F-PB22 is a synthetic cannabinoid, a chemical designed to mimic the effects of cannabinoids found naturally in the cannabis plant. Synthetic cannabinoids have gained attention due to their use in recreational drug markets and their potential applications in scientific research. However, they also pose significant risks because of their potency, unpredictable effects, and sometimes unknown toxicology.

This overview will cover the chemical nature, pharmacology, effects, risks, and legal status of 5F-PB22 to provide a comprehensive understanding suitable for educational purposes.

Chemical Nature and Structure

5F-PB22 is chemically known as quinolin-8-yl 1-(5-fluoropentyl)-1H-indole-3-carboxylate. It belongs to the broader class of indole-based synthetic cannabinoids, which are characterized by an indole core structure connected to various side chains and functional groups.

The “5F” in its name indicates the presence of a fluorine atom attached to the fifth carbon of the pentyl side chain, a common modification in synthetic cannabinoids that often enhances potency and alters metabolic stability.

The molecular structure can be broken down as follows:

• Indole core: A bicyclic structure composed of a benzene ring fused to a pyrrole ring.

• Carboxylate ester linkage: Connecting the indole core to a quinoline ring (quinolin-8-yl group).

• 5-fluoropentyl side chain: A pentyl chain with a fluorine atom at the terminal end, influencing receptor affinity.

This structure allows 5F-PB22 to interact with cannabinoid receptors in the human body.

Pharmacology
5F-PB-22 acts as a full agonist with a binding affinity of 0.468 nM at CB1 and 0.633 nM at CB2cannabinoid receptors.

Chemical and physical data
Formula: C23H21FN2O2

Molar mass: 376.431 g·mol?1

Technical Information

Formal Name1-(5-fluoropentyl)-8-quinolinyl ester-1H-indole-3-carboxylic acid
CAS Number1400742-41-7
Molecular FormulaC23H21FN2O2
Formula Weight376.4
Purity?98%
FormulationA neat solid
SMILESO=C(OC1=C(N=CC=C2)C2=CC=C1)C3=CN(CCCCCF)C4=C3C=CC=C4
InChi CodeInChI=1S/C23H21FN2O2/c24-13-4-1-5-15-26-16-19(18-10-2-3-11-20(18)26)23(27)28-21-12-6-8-17-9-7-14-25-22(17)21/h2-3,6-12,14,16H,1,4-5,13,15H2
InChi KeyMBOCMBFDYVSGLJ-UHFFFAOYSA-N
WARNING This product is not for human or veterinary use.

Shipping & Storage Information
Storage: -20°C
Shipping: Room Temperature in continental US; may vary elsewhere
Stability: ? 3 years