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3-MMC, or 3-Methylmethcathinone, is a synthetic cathinone of the phenethylamine and amphetamine chemical classes. Structurally similar to mephedrone (4-MMC), 3-MMC is widely studied for its potential monoamine reuptake inhibition effects—primarily on dopamine, serotonin, and norepinephrine transporters.

Chemical Properties of 3-MMC

Research Applications of 3-MMC

3-MMC is used extensively in neurochemical, pharmacological, and forensic contexts.

Common uses include:

• Transporter binding assays (DAT, SERT, NET)

• Structure–activity relationship (SAR) comparisons with 4-MMC

• Toxicology profiling and synthetic stimulant research

• Calibration standard in LC-MS/MS and GC-MS

• Metabolic pathway analysis in vitro

Researchers continue to explore 3-MMC’s receptor affinity and inhibition properties, comparing its stimulant and entactogenic activity to other synthetic cathinones.

Legal Status of 3-MMC in Europe

3-MMC has been banned or restricted in several European countries, including under analogue or psychoactive substance laws.

• Germany: Controlled under NpSG

• France: Listed as a banned psychoactive substance

• Sweden, UK, Netherlands: Generally restricted under cathinone-related regulations

• Other EU nations: May vary; always confirm before ordering

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Due to its stimulant nature, 3-MMC should be handled with caution and only in secure, approved laboratories.

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5F-ADB, also known as 5F-MDMB-PINACA, is a potent synthetic cannabinoid that acts on the CB1 and CB2 receptors in the endocannabinoid system. It is widely studied for its pharmacological effects, receptor binding profiles, and metabolic pathways.

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Are you looking to buy 5F-MN24 powder in Europe from a reliable and professional research chemical supplier? At ResearchChemAsia.com, we offer high-purity 5F-MN24 (also known as 5F-NNE1) in powder form, available exclusively for scientific, analytical, and forensic research.

As a leading provider of research-grade cannabinoids and related compounds, we ensure that all products are lab-tested, discreetly shipped, and fully compliant with EU regulations. Whether you are studying cannabinoid receptor activity, developing detection methods, or conducting forensic profiling, our 5F-MN24 supports your work with consistency and quality.

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5F-MN24, also referred to as 5F-NNE1, is a synthetic cannabinoid and member of the indazole-3-carboxamide family. It is structurally related to compounds such as 5F-AKB48 and 5F-PB-22, and it has been used in research to explore interactions with CB1 and CB2 receptors in the endocannabinoid system.

In laboratory settings, 5F-MN24 is studied for:

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Are you a researcher based in Europe looking to buy 5F‑SDB‑005 powder safely and legally? At ResearchChemAsia.com, we support your analytical and forensic research needs with the highest-quality synthetic cannabinoid reference standards. In this guide, you’ll discover trusted European suppliers, legal considerations, safety protocols, and how ResearchChemAsia.com can assist—so you can procure and use 5‑fluoro SDB‑005 with confidence.

What Is 5F‑SDB‑005 Powder?

5F‑SDB‑005, also known as naphthalen‑1‑yl 1‑(5‑fluoropentyl)‑1H‑indazole‑3‑carboxylate, is a synthetic cannabinoid receptor agonist used exclusively in research and forensic contexts. It exhibits potent activity at CB₁ (EC₅₀ ≈ 21 nM) and CB₂ (EC₅₀ ≈ 140 nM) receptors.Its high-purity (≥98%) powder form ensures precision in assays and validity in analytical applications. Storage at −20 °C maintains shelf life (≥2 years), and it dissolves well in solvents like DCM, DMF, and DMSO.

Where to Buy 5F‑SDB‑005 in Europe

Several European vendors supply 5F‑SDB‑005 or its closely related analogs.

When choosing a supplier, consider factors like purity certification, shipping reliability, legal compliance, and batch traceability.

Legal & Safety Considerations

The legal status of synthetic cannabinoids like 5F‑SDB‑005 varies across Europe. Some countries regulate them under analogue or generic drug laws, while others allow possession strictly for scientific research.(WikiMD, Wikipedia) It’s essential to verify local regulations before ordering.

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Are you a laboratory or institution looking to buy 5FN‑PB22 powder in Europe? At ResearchChemAsia.com, we offer premium-grade research chemicals to support scientific and analytical work across disciplines. One of our most requested compounds, 5FN‑PB22, is a potent synthetic cannabinoid available exclusively for laboratory use and forensic analysis.

In this article, we’ll cover what 5FN‑PB22 is, its chemical structure, its relevance in research, safety information, and how to obtain high-quality 5FN‑PB22 powder securely and legally.

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5FN‑PB22, sometimes referred to as 5F‑PB‑22, is a synthetic cannabinoid designed to act as a potent agonist for the CB1 and CB2 receptors in the endocannabinoid system. It is not intended for human or veterinary consumption, and its use is strictly limited to analytical reference and forensic research.

This compound is often studied in comparison to natural cannabinoids due to its high binding affinity and psychoactive properties observed in laboratory models. Its structure is derived from the indole class of synthetic cannabinoids and includes a 5‑fluoropentyl chain which enhances its potency and receptor activity.

Chemical Profile

• IUPAC Name: Quinolin-8-yl 1-(5-fluoropentyl)-1H-indole-3-carboxylate
• Molecular Formula: C₂₃H₂₁FN₂O₂
• Molecular Weight: ~376.4 g/mol
• Appearance: White or off-white crystalline powder
• Purity: Typically ≥98% when sourced from reputable suppliers like ResearchChemAsia.com

This compound is highly lipophilic, contributing to its strong central activity and making it an ideal candidate for laboratory research on receptor-ligand interactions and synthetic cannabinoid profiling.

Applications in Research

5FN‑PB22 is utilized in research environments to:

• Study cannabinoid receptor function (CB1 and CB2 binding affinities)
• Develop forensic testing methods for synthetic cannabinoid detection
• Analyze metabolic breakdown pathways
• Create calibration curves for analytical instruments like GC/MS and LC/MS

Because of its potency, it plays a significant role in toxicological and forensic casework related to synthetic cannabinoid exposure.

Safety & Handling Guidelines

Working with 5FN‑PB22 requires strict adherence to laboratory safety standards. Although it is used in research, it poses several potential hazards:

Hazard Statements:

• Harmful if inhaled, swallowed, or absorbed through the skin
• May cause respiratory irritation
• May cause long-lasting harmful effects in aquatic environments

Precautions:

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• Do not allow the substance to enter drains or waterways
• Store in a tightly sealed container at -20°C in a dry, ventilated space
• Keep away from direct sunlight and heat sources

Legal Status in Europe

The legality of 5FN‑PB22 varies between European countries. Some nations have placed it under controlled substance laws due to its similarity to other synthetic cannabinoids. However, in several jurisdictions, it remains legal for licensed research purposes.

Researchers and institutions are strongly advised to:

• Verify the legal status of 5FN‑PB22 in their region before ordering
• Ensure they are authorized to purchase and possess controlled research substances
• Maintain full documentation including Certificates of Analysis (COAs) and Material Safety Data Sheets (MSDS)

At ResearchChemAsia.com, we only supply research chemicals to verified laboratories and professionals in accordance with international compliance standards.

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If you’re looking to buy ADB-FUBINACA powder in Europe, you’re likely involved in chemical research, forensic analysis, or synthetic cannabinoid studies. As one of the most potent synthetic cannabinoids developed to date, ADB-FUBINACA continues to draw attention from academic researchers and toxicologists due to its strong affinity for CB1 receptors and its role in synthetic cannabis products.

In this guide, we’ll cover everything you need to know before sourcing ADB-FUBINACA powder in Europe, including what it is, how it’s used in research, legal concerns, and how to safely choose a reliable supplier.

What Is ADB-FUBINACA Powder?

ADB-FUBINACA is a synthetic cannabinoid, originally developed by Pfizer in 2009 as part of their analgesic research. It is a potent CB1 and CB2 receptor agonist, known for producing effects similar to THC but with significantly higher binding affinity.

• Full Name: N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide

• Molecular Formula: C21H23FN4O2

• Appearance: Off-white to beige crystalline powder

• Potency: High (often active at sub-milligram levels)

It has been identified in numerous synthetic cannabinoid blends sold as “herbal incense” or “legal highs,” particularly before global bans took effect.

Why Researchers Purchase ADB-FUBINACA Powder

1. Cannabinoid Receptor Studies

Due to its extreme potency, ADB-FUBINACA is frequently used to investigate CB1 receptor activation, endocannabinoid system pathways, and G-protein coupled receptor (GPCR) signaling.

2. Forensic & Toxicological Research

ADB-FUBINACA has been found in dozens of synthetic cannabis products across Europe and North America. Forensic labs use it to:

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• Develop mass spectrometry profiles

• Study overdose-related cases

3. Pharmacological Profiling

Because of its structural uniqueness, ADB-FUBINACA contributes to SAR (structure-activity relationship) studies for designing safer synthetic cannabinoids or identifying dangerous analogs.

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Synthetic cannabinoid FAB‑144 has garnered attention across European research institutions for its potent CB₁ receptor activity and structural similarity to XLR‑11. Whether you’re considering procurement for forensic analysis, medicinal chemistry, or academic study, it’s imperative to assess legal frameworks, supplier credibility, technical specifications, and safety protocols—especially within a European context.

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FAB‑144 is an indazole-based synthetic cannabinoid, functioning as an analog of XLR‑11 but with an indazole core instead of an indole one WikipediaGlpBio. Its molecular formula is C₂₀H₂₇FN₂O with a molecular weight of ~330.4 g/mol bertin-bioreagent.comNCATS Inxight Drugs. While it’s believed to act as a potent CB₁ receptor agonist, definitive physiological and toxicological profiles remain largely undocumented GlpBioResearchGateWikipedia.

Physicochemical Profile

• Structural identifiers include SMILES and InChI codes that map its precise structure. WikipediaNCATS Inxight Drugs

• Predicted properties:

  • Boiling point: ~436 °C

  • Density: ~1.13 g/cm³

  • Solubility: ~30 mg/mL in DMF, DMSO, ethanol; ~0.2 mg/mL in ethanol/PBS (1:4)

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Due to its high potency and unknown toxicity, FAB‑144 must be handled with extreme caution. Key considerations include:

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• Research Applications

  FAB‑144 is marketed strictly for research or forensic use only, with manufacturers expressly prohibiting human consumption . Early pharmacological screening shows that FAB‑144 displays increased affinity for both CB₁ and CB₂ receptors, although data remains limited ResearchGatePMC. These profiles suggest potential value in receptor binding studies and molecular pharmacology—though the data is preliminary.

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JWH-018 is one of the most well-known synthetic cannabinoids, widely used in scientific research to study cannabinoid receptors and their effects. If you are interested in understanding what JWH-018 is, its applications, and how to buy it safely for research purposes, this article has you covered.

JWH-018 (1-pentyl-3-(1-naphthoyl)indole, NA-PIMO or AM-678) is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB₁ and CB₂ cannabinoid receptors, with some selectivity for CB₂. It produces effects in animals similar to those of tetrahydrocannabinol (THC), a cannabinoid naturally present in cannabis, leading to its use as synthetic cannabinoid products that, in some countries, are sold legally as “incense blends”.

As a full agonist at both the CB₁ and CB₂ cannabinoid receptors, this chemical compound is classified as an analgesic medication.The analgesic effects of cannabinoid ligands, mediated by CB₁ receptors are well established in treatment of neuropathic pain, as well as cancer pain and arthritis.

These compounds work by mimicking the body’s naturally-produced endocannabinoid hormones such as 2-AG and anandamide (AEA), which are biologically active and can exacerbate or inhibit nerve signaling. As the cause is poorly understood in chronic pain states, more research and development must be done before the therapeutic potential of this class of biologic compounds can be realized

What is JWH-018?

JWH-018 is a synthetic cannabinoid belonging to the naphthoylindole family. It acts as a potent agonist of the CB1 receptor, which is the same receptor activated by THC, the active ingredient in cannabis. Developed initially for pharmacological research, JWH-018 helps scientists understand cannabinoid receptor activity and potential therapeutic applications.

Typically, JWH-018 appears as a white or off-white crystalline powder, which can be used in analytical chemistry and forensic investigations.

Common Uses of JWH-018 in Research

• Pharmacological studies on cannabinoid receptor binding and activation

• Toxicology and forensic analysis for detection of synthetic cannabinoids

• Drug screening development in clinical and forensic laboratories

• Structure-activity relationship (SAR) studies to explore analog compounds

Its potent action on cannabinoid receptors makes it valuable for understanding how cannabinoids influence the nervous system.

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5F-ADB, also known as 5F-MDMB-PINACA, is a synthetic cannabinoid receptor agonist, developed to mimic the psychoactive effects of delta-9-tetrahydrocannabinol (THC). It is part of a group of chemicals known as new psychoactive substances (NPS) or “legal highs.” These substances are often sold under brand names like “Spice”, “K2”, or “herbal incense”, but they contain synthetic chemicals sprayed onto plant material.

5F-ADB is one of the most potent synthetic cannabinoids ever studied, with binding affinity to cannabinoid receptors (CB1 and CB2) far stronger than THC—meaning it acts more aggressively and with potentially dangerous outcomes.

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• IUPAC Name: Methyl (2S)-2-{[1-(5-fluoropentyl)-1H-indazole-3-carbonyl]amino}-3,3-dimethylbutanoate

• Molecular Formula: C20H28FN3O3

• Chemical Class: Indazole-based synthetic cannabinoid

• Common Forms: Powder, liquid, sprayed on plant material

• Street Names: 5F-ADB, 5F-MDMB-PINACA, “Spice”, “K2”, “Herbal High”

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5F-ADB binds to CB1 receptors in the brain, the same receptors targeted by THC. However, it binds with much higher affinity, leading to more intense and unpredictable effects. The CB1 receptor is involved in regulating:

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• Motor control

By overstimulating these receptors, 5F-ADB can cause severe toxicity and psychiatric symptoms.

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Acute Effects (can begin within minutes):

• Extreme euphoria or dysphoria

• Hallucinations

• Intense anxiety or panic attacks

• Paranoia

• Disorientation or confusion

• Agitation and aggression

• Nausea or vomiting

• Tachycardia (fast heart rate)

• Seizures

• Loss of consciousness

Severe and Fatal Reactions:

• Respiratory depression

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• Cardiac arrest

• Coma

• Death

Even in small doses, 5F-ADB has caused fatal overdoses, especially when used unknowingly in mixed or mislabeled products.

Medical Emergencies 

Emergency departments have reported:

• Hundreds of hospitalizations

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• Clusters of overdoses in prisons and homeless shelters

• Deaths due to multi-organ failure or cardiac arrest

In 2018, the CDC (Centers for Disease Control and Prevention) investigated dozens of deaths in the U.S. where 5F-ADB was a primary or contributing factor.

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2-MMC stands for 2-Methylmethcathinone, a synthetic stimulant belonging to the substituted cathinone family. Cathinones are chemicals structurally related to cathinone, the active stimulant in the khat plant, but 2-MMC is a synthetic “designer drug” or research chemical designed to mimic the effects of controlled stimulants like methamphetamine or mephedrone.

2-MMC is typically found as a white or off-white crystalline powder and is consumed recreationally for its stimulant and euphoric effects.

Chemical Properties

• Chemical Class: Substituted cathinone

• Chemical Formula: C11H15NO

• IUPAC Name: 2-methylmethcathinone

• Appearance: White to off-white powder or crystals

• Solubility: Soluble in water and organic solvents

• Related Compounds: Mephedrone (4-MMC), 3-MMC (3-methylmethcathinone)

Pharmacology and Mechanism of Action

2-MMC acts as a central nervous system stimulant by increasing the levels of certain neurotransmitters in the brain, mainly:

• Dopamine – involved in reward, motivation, and pleasure

• Norepinephrine – responsible for alertness and energy

• Serotonin – plays a role in mood and social behavior (to a lesser extent than some other cathinones)

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Effects of 2-MMC

Users report stimulant-like effects similar to other cathinones and amphetamines, including:

• Euphoria and increased sociability

• Enhanced energy and alertness

• Increased heart rate and blood pressure

• Reduced appetite

• Increased focus or talkativeness

• Mild empathy or mood lift

The effects generally begin within 15–30 minutes of consumption and can last between 3 to 5 hours depending on dose and administration method.

Common Routes of Administration

• Oral ingestion (swallowing powder, capsules, or solutions)

• Insufflation (snorting the powder)

• Vaporization or smoking (less common)

• Injection is rare and highly dangerous, and not recommended.

Potential Risks and Side Effects

While formal research on 2-MMC is limited, it shares side effect profiles typical of stimulant cathinones, including:

• Increased heart rate and blood pressure

• Anxiety or nervousness

• Insomnia or sleep disturbances

• Jaw clenching or muscle tension

• Headache or dizziness

• Nausea or gastrointestinal discomfort

• Paranoia or agitation (especially at high doses)

• Risk of dependency or abuse with repeated use

More serious adverse effects, such as cardiac events or psychosis, are possible but less documented for 2-MMC specifically.

Addiction and Dependency

2-MMC has potential for psychological dependence due to its dopamine-releasing properties. Users may develop tolerance, requiring higher doses to achieve the same effects, which increases risk of side effects and harm.

Legal Status

2-MMC is often sold as a “research chemical” and may not be explicitly listed in controlled substances schedules in some countries. However, many jurisdictions include cathinone derivatives in analogue laws or blanket bans on synthetic stimulants, making possession, sale, or use illegal. Buy 2-MMC Europe , Purchase 2-MMC powder Germany , Order 2-MMC online France , 2-MMC for sale Italy , 2-MMC research chemical Australia

Always check local laws before handling substances like 2-MMC.

Harm Reduction Advice

• Test the substance for purity and presence of dangerous adulterants before use.

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JWH-307 is a synthetic cannabinoid that belongs to a group of laboratory-created compounds designed to mimic the effects of THC, the psychoactive chemical found in cannabis. It was developed by chemist John W. Huffman, whose research into the endocannabinoid system led to the synthesis of hundreds of cannabinoids for scientific study.

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These compounds were not initially created for recreational use but became part of the unregulated drug market in the late 2000s and early 2010s. JWH-307, like many others in the JWH-series, was sold in products labeled as “herbal incense” or “legal highs,” often under names like “Spice” or “K2.”

Chemical Structure and Classification | Research chemical vendor Europe

JWH-307 is part of the naphthoylpyrrole family of synthetic cannabinoids. Its chemical name is (5-(2-fluorophenyl)-1-pentylpyrrol-3-yl)(naphthalen-1-yl)methanone.

Key chemical properties:

• Molecular Formula: C₂₆H₂₄FNO

• Molecular Weight: ~385.5 g/mol

• Structural Class: Naphthoylpyrrole

• Appearance: Typically a white to off-white powder in its raw form.

The structure features a naphthalene ring, a fluorinated phenyl group, and a pyrrole ring with a pentyl chain. These groups are responsible for binding the compound to cannabinoid receptors in the human body.

Mechanism of Action

JWH-307 functions as an agonist at cannabinoid receptors CB1 and CB2, which are part of the human endocannabinoid system. These receptors help regulate mood, memory, pain sensation, and appetite.

• CB1 receptors are found primarily in the brain and central nervous system.

• CB2 receptors are mostly found in peripheral organs, especially those involved in immune function.

JWH-307 has moderate selectivity for the CB2 receptor, meaning it binds slightly more readily to CB2 than CB1. Its binding affinity (measured by Ki values) is approximately:

• 7.7 nanomolar (nM) at CB1

• 3.3 nanomolar (nM) at CB2

These values indicate that JWH-307 is highly potent, binding strongly to both receptors at extremely low concentrations. This makes the compound pharmacologically active in microgram quantities.

Buy JWH-307 Crystal, it is an analgesic drug used in scientific research, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors. It is somewhat selective for the CB2 subtype, with a Ki of 7.7 nM at CB1 vs 3.3 nM at CB2. JWH-307 was detected as an ingredient in synthetic cannabis smoking blends in 2012, initially in Germany. JWH 307 5?-Isomer is an analogue of JWH 307 (J211800), a cannabimimetic that potently activates both the central cannabinoid (CB) receptor, CB1, and the peripheral CB2 receptor (Ki = 7.7 and 3.3 nM, respectively). The affinities of JWH-307 for both CB1 (Ki = 7.7 nM) and CB2 (Ki = 3.3 nM) are comparable to those of the traditional cannabinoid.

Technical Information
Formal Name: [5-(2-fluorophenyl)-1-pentyl-1H-pyrrol-3-yl]-1-naphthalenyl-methanone
CAS Number: 914458-26-7
Molecular Formula: C26H24FNO
Formula Weight: 385.5
Purity: ?96%
Formulation: A crystalline solid
?max: 217, 250 nm
SMILES: O=C(C1=CN(CCCCC)C(C2=CC=CC=C2F)=C1)C3=C4C(C=CC=C4)=CC=C3
InChi CodeInChI=1S/C26H24FNO/c1-2-3-8-16-28-18-20(17-25(28)23-13-6-7-15-24(23)27)26(29)22-14-9-11-19-10-4-5-12-21(19)22/h4-7,9-15,17-18H,2-3,8,16H2,1H3
InChi Key: WYNZPDDTQGVCLZ-UHFFFAOYSA-N
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See also
JWH-147
WARNING This product is not for human or veterinary use.

JWH-250 or (1-pentyl-3-(2-methoxyphenylacetyl)indole) is an analgesic chemical from the phenylacetylindole family that acts as a cannabinoid agonist at both the CB1 and CB2 receptors, with a Ki of 11 nM at CB1 and 33 nM at CB2. Unlike many of the older JWH series compounds, this compound does not have a naphthalene ring, instead occupying this position with a 2?-methoxy-phenylacetyl group, making JWH-250 a representative member of a new class of cannabinoid ligands. Other 2?-substituted analogues such as the methyl, chloro and bromo compounds are also active and somewhat more potent.

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UR-144 is a synthetic cannabinoid, a type of lab-created chemical that mimics the effects of THC, the primary psychoactive component in cannabis. First synthesized in the early 2010s by scientists researching the endocannabinoid system, UR-144 soon found its way into the “legal high” or “spice” market—sold in herbal smoking blends or as a pure powder for recreational use.

Although synthetic cannabinoids like UR-144 were initially marketed as legal alternatives to cannabis, they are not safe substitutes. UR-144 and its analogues have been associated with serious health risks, including seizures, psychosis, cardiovascular issues, and even death. This article provides a comprehensive, educational look at UR-144: what it is, how it works, and why it presents significant risks.

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UR-144 has high affinity for the CB2 receptor with a Ki of 1.8 nM but 83x lower affinity for the CB1 receptor with a Ki of Associate in Nursingd fifty} nM. it absolutely was found to possess an EC50 of 421 nM for human CB1 receptors, and seventy two nM for human CB2 receptors. UR-144 produces arrhythmia and physiological state in rats at a dose of ten mg/kg, suggesting weak cannabinoid-like activity.

with chemicals it’s closely concerning alternative 2,2,3,3-tetramethylcyclopropyl artificial cannabinoids like A-796,260 and A-834,735 however with a special substitution on the 1-position of the indole core, in these compounds its 1-pentyl cluster is replaced with alkylheterocycles like 1-(2-morpholinoethyl) and 1-(tetrahydropyran-4-ylmethyl).

Chemical and physical information
Formula: C21H29NO

Molar mass: 311.461 g/mol g·mol?1

Dose
Inhalation (tentative because of an absence of information)

Range: 2.5 to twenty mg
the general public are exposed to the drug within the type of “blends” that contain variable levels of UR-144. It’s not informed use those products.

Timeline
Inhalation (tentative because of an absence of information)
Total: one – two hours
Onset: below ten minutes
see

Mechanism of Action

UR-144 acts primarily as a full agonist at the CB2 receptor, and to a lesser extent at the CB1 receptor. These receptors are part of the body’s endocannabinoid system:

• CB1 receptors: Found mainly in the central nervous system (brain and spinal cord), responsible for psychoactive effects

• CB2 receptors: Found mostly in the immune system and peripheral tissues

Compared to THC, which is a partial agonist of CB1, UR-144 binds more strongly and activates the receptors more fully, which can lead to unpredictable and intense effects, even at low doses.

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purchase THJ-2201 crystal AN indazole-based artificial cannabinoid that presumptively acts as a potent agonist of the CB1 receptor and has been sold on-line as a designer drug. Buy THJ-2201 Crystal

it’s a structural analog of AM-2201 within which the central indole ring has been replaced by indazole.

outline sheet: THJ-2201
THJ-2201 (1-?[(5-?fluoropentyl)-?1H-?indazol-?3-?yl](naphthalen-?1-?yl)methanone) could be a synthetic cannabinoid and analog of AM-2201. it’s been marketed by several analysis chemical vendors as a legal various to the favored AM-2201, which had been prohibited in 2011.

Cannabinoids are unremarkably smoke-dried or vaporized to attain a fast onset of effects and speedy offset. THJ-2201 is orally active once dissolved during a lipid, which may increase the period significantly. Like alternative cannabinoids, it’s insoluble in water however dissolves in plant product and lipids.

not like cannabis, the chronic abuse of artificial cannabinoids has been related to multiple deaths and additional dangerous facet effects and toxicity in general. Therefore, it is powerfully discouraged to require this substance for extended periods of your time or in excessive doses.Buy THJ-2201 Crystal Europe , where to order THJ-2201 Crystal Online Germany , THJ-2201 Crystal for sale in France , Purchase THJ-2201 Crystal Austria

medicine
though this substance has not been formally studied, from analysis of the structure, it’s likely that THJ-2201 encompasses a similar binding profile to it of AM-2201 and matches several of the in vivo properties of ?9-THC. like AM-2201, this compound is believed to act as a potent full agonist to the central CB1 and peripheral CB2 receptors with Ki values of 1.0 and 2.6nM respectively. However, the role of those interactions and the way they lead to the cannabinoid high expertise continues to stay elusive.

Subjective effects
the results listed below are primarily based upon the subjective effects index and private experiences of PsychonautWiki contributors. These effects should be soft on a grain of salt and can seldom (if ever) occur all at once, however heavier doses will increase the probabilities of inducement a full vary of effects. Likewise, adverse effects become far more probably on higher doses and will embody serious injury or death.

Chemical and physical knowledge
Formula C23H21FN2O
Molar mass 360.42 g/mol g·mol?1
3D model (JSmol) Interactive

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SDB-006 is a synthetic cannabinoid, part of a growing class of man-made chemicals designed to mimic the psychoactive effects of THC (delta-9-tetrahydrocannabinol), the active ingredient in cannabis. Sold online and in some head shops as a “legal high,” SDB-006 has been linked to significant health risks, including toxicity, overdose, and severe adverse reactions.

This article provides an educational look at SDB-006—what it is, how it works, its effects, risks, and its status in the evolving legal landscape.

What is SDB-006?

• Chemical name: N-[(2S)-1-amino-3,3-dimethyl-1-oxobutan-2-yl]-1-(cyclohexylmethyl)-1H-indazole-3-carboxamide

• Chemical class: Indazole-based synthetic cannabinoid

• Molecular formula: C22H30N4O2

• Molar mass: Approximately 386.50 g/mol

SDB-006 is structurally similar to other synthetic cannabinoids such as AB-FUBINACA and ADB-FUBINACA, which have appeared frequently in the “legal high” market since the early 2010s.

Buy SDB-006 Powder SDB-006 is a drug that acts as a potent agonist for the cannabinoid receptors, with an EC50 of 19 nM for human CB2 receptors, and 134 nM for human CB1 receptors. It was discovered during research into the related compound SDB-001 which had been sold illicitly as “2NE1”. SDB-006 metabolism has been described in literature.

Synthetic cannabinoids are the largest and most structurally diverse class of new psychoactive substances, with manufacturers often using isomerism to evade detection and circumvent legal restriction. The regioisomeric methoxy? and fluorine?substituted analogs of SDB?006 (N?benzyl?1?pentyl?1H?indole?3?carboxamide) were synthesized and could not be differentiated by gas chromatography–mass spectrometry (GC–MS), but were distinguishable by liquid chromatography–quadrupole time?of?flight–MS (LC–QTOF–MS). In a fluorescence?based plate reader membrane potential assay, SDB?006 acted as a potent agonist at human cannabinoid receptors (CB1 EC50 = 19 nM). All methoxy? and fluorine?substituted analogs showed reduced potency compared to SDB?006, although the 2?fluorinated analog (EC50 = 166 nM) was comparable to known synthetic cannabinoid RCS?4 (EC50 = 146 nM). Using biotelemetry in rats, SDB?006 and RCS?4 evoked comparable reduction in body temperature (~0.7°C at a dose of 10 mg/kg), suggesting lower potency than the recent synthetic cannabinoid AB?CHMINACA (>2°C, 3 mg/kg).

Technical Information
Formal Name: 1-pentyl-N-(phenylmethyl)-1H-indole-3-carboxamide
CAS Number: 695213-59-3
Molecular Formula: C21H24N2O
Formula Weight: 320.4
Purity: ?98%
Formulation: A crystalline solid
?max: 218, 291 nm
SMILES: CCCCCN1C=C(C(NCC2=CC=CC=C2)=O)C3=C1C=CC=C3
InChi CodeInChI=1S/C21H24N2O/c1-2-3-9-14-23-16-19(18-12-7-8-13-20(18)23)21(24)22-15-17-10-5-4-6-11-17/h4-8,10-13,16H,2-3,9,14-15H2,1H3,(H,22,24)
InChi Key: OLACYTSBFXCDOH-UHFFFAOYSA-N
Shipping & Storage Information
Storage: -20°C
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Stability: ? 2 years
WARNING This product is not for human or veterinary use.

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SDB-005 is a synthetic cannabinoid that appeared on the gray market as part of the wave of “research chemicals” or so-called “legal highs.” Often found in powder form, SDB-005 has no approved medical use and is chemically engineered to mimic the psychoactive effects of THC (the active ingredient in cannabis).

Although originally marketed as a legal alternative to marijuana, SDB-005 and its analogs have been associated with severe health risks, including toxicity, psychosis, and death. This article provides an educational overview of SDB-005 powder—its structure, effects, potential dangers, and regulatory status.

These chemicals are often sprayed on herbal mixtures and sold under names like “Spice,” “K2,” or “herbal incense.”

• Chemical name: N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-pentyl-1H-indazole-3-carboxamide

• Chemical class: Indazole-based synthetic cannabinoid

• Molecular formula: C19H28N4O2

• Molar mass: ~344.46 g/mol

• Appearance: Typically a white or off-white crystalline powder

SDB-005 is structurally related to other synthetic cannabinoids like ADB-005 and SDB-006, and shares many of their pharmacological and toxicological characteristics.

Buy SDB-005 powder online, it is an indazole-based synthetic cannabinoid that has been sold online as a designer drug. It is presumed to be an agonist of the CB1 and CB2 cannabinoid receptors. SDB-005 is the indazole core analog of PB-22 where the 8-hydroxyquinoline has also been replaced with a naphthalene group.

The code number SDB-005 was originally used for a different compound, the N-phenyl instead of N-benzyl analogue of SDB-006. This compound is a potent agonist of the CB1 receptor (Ki = 21 nM) and CB2 receptor (Ki = 140 nM).BUY SDB-005 POWDER Europe , Where to order research chemical Online Europe ,SDB-005 for sale Germany , Purchase SDB-005 France , SDB-005 Vendor spain

However, SDB-005 was subsequently used as the name for the indazole-3-carboxylate compound mentioned above when it was sold in Europe as a designer drug, and was entered into the EMCDDA synthetic drug database under this name. Consequently, there are now two distinct, yet fairly closely related cannabinoid compounds, which may both be referred to under the code SDB-005.

Technical Information
Formal Name: naphthalen-1-yl 1-pentyl-1H-indazole-3-carboxylate
Molecular Formula: C23H22N2O2
Formula Weight: 358.4
Purity: ?98%
Formulation: A crystalline solid
?max: 220, 300 nm
SMILES: O=C(OC1=C(C=CC=C2)C2=CC=C1)C3=NN(CCCCC)C4=CC=CC=C43
InChi CodeInChI=1S/C23H22N2O2/c1-2-3-8-16-25-20-14-7-6-13-19(20)22(24-25)23(26)27-21-15-9-11-17-10-4-5-12-18(17)21/h4-7,9-15H,2-3,8,16H2,1H3
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Storage: -20°C
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Stability: ? 2 years
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Buy MAM-2201 crystal MAM-2201 (4?-methyl-AM-2201, 5?-fluoro-JWH-122) is a drug that presumably acts as a potent agonist for the cannabinoid receptors.

Details to buy MAM-2201 crystal
Synonyms JWH 122 N-pentanoic acid metabolite
MAM2201 (Item No. 9001219) is a synthetic cannabinoid (CB) that is closely related, structurally, to AM2201 (Item No. 10707) and JWH 122 (Item No. 10591), two compounds which display high affinities for both CB receptors. MAM2201 N-pentanoic acid metabolite is a potential phase 1 metabolite of MAM2201 or JWH 122, based on the known metabolism of similar compounds. The physiological and toxicological properties of this compound have not been evaluated. This product is intended for forensic and research applications.Buy MAM-2201 crystal Europe , MAM-2201 crystal For sale Online France , Where to order research chemical Germany, MAM-2201 crystal Vendor Eu

Technical Information
Formal Name: [1-(5-fluoropentyl)-1H-indol-3-yl](4-methyl-1-naphthalenyl)-methanone

CAS Number:1354631-24-5
Molecular Formula:
C25H24FNO
Formula Weight:
373.5
Purity:
?98%
Formulation: A neat solid
SMILES: FCCCCCN1C2=CC=CC=C2C(C(C3=CC=C(C)C4=C3C=CC=C4)=O)=C1
InChi Code: InChI=1S/C25H24FNO/c1-18-13-14-22(20-10-4-3-9-19(18)20)25(28)23-17-27(16-8-2-7-15-26)24-12-6-5-11-21(23)24/h3-6,9-14,17H,2,7-8,15-16H2,1H3
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Why is MAM-2201 used?
MAM-2201 generally used for the following reasons: Mood enhancement, euphoria, general arousal, body pleasure, change in awareness, relaxation etc. Please note that MAM-2201 generally smoked into human body. This process can be completed chemically or with help of the herbal blends as well. Apart from being a medicine, MAM-2201 often used as a research chemical in various laboratories all over the world too.

Presumably, known to act as a potent against the cannabinoid receptors. The element initially identified in June, 2011 in German and Dutch laboratories as one of the ingredients in the synthetic cannabis smoking blends.

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Buy FUB-PB22 Powder, it is an indole-based synthetic cannabinoid that is a potent agonist of the CB1 receptor and has been sold online as a designer drug.FUB-PB-22 is a synthetic cannabinoid that has attracted attention in both forensic science and drug policy discussions. Originally developed for research purposes, this compound has become known due to its presence in “legal high” products and its classification as a new psychoactive substance (NPS). This article will explore the chemical nature of FUB-PB-22, its potential effects, legal status, and associated health risks.

FUB-PB22 with the formal name of quinolin-8-yl 1-(4-fluorobenzyl)-1H-indole-3-carboxylate and is a substitute of 5F-PB22 and PB22. The molecular formula is C25H17FN2O2 with a molecular weight of 396.41 and an exact mass of 396.13. FUB-PB22 is a white powder, developed on an indazole base, which sets it apart from several other JWH compounds having an indolyl base. At this time, research on FUB-PB22 has not determined the biochemical, physiological, and toxicological properties, thus more research is needed.

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Chemical Properties

• Molecular formula: C26H20FN3O2

• Molecular weight: Approximately 425.45 g/mol

• Structure type: Indole-based synthetic cannabinoid

• Receptor activity: High affinity agonist at the CB1 and CB2 cannabinoid receptors

FUB-PB-22 acts as a potent agonist at the CB1 receptor, which is found primarily in the central nervous system, and the CB2 receptor, located mainly in immune tissues. These receptors are part of the body’s endocannabinoid system, which regulates mood, pain, appetite, and other physiological processes.

Pharmacology

FUB-PB-22 acts as a full agonist with a binding affinity of 0.386nM at CB1 and 0.478nM at CB2cannabinoid receptors.

Legal status
FUB-PB-22 is a Anlage II controlled substance in Germany. It was scheduled in Japan in July 2014.

As of October 2015 FUB-PB-22 is a controlled substance in China.

It is also banned in Sweden.

Chemical and physical data
Formula: C25H17FN2O2

Molar mass: 396.41 g/mol g·mol?1

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Buy BB-22 Powder Online (QUCHIC or 1-(cyclohexylmethyl)-1H-indole-3-carboxylic acid 8-quinolinyl ester) is a designer drug offered by online vendors as a cannabimimetic agent, and was first detected being sold in synthetic cannabis products in Japan in early 2013, and subsequently also in New Zealand. The structure of QUCHIC appears to use an understanding of structure-activity relationships within the indole class of cannabimimetics, although its design origins are unclear. QUCHIC, along with QUPIC, represents a structurally unique synthetic cannabinoid chemotype since it contains an ester linker at the indole 3-position rather than the precedented ketone of JWH-018 and its analogues, or the amide of SDB-001 and its analogues.

Chemical and physical data
Formula: C25H24N2O2

Molar mass: 384.47 g/mol g·mol?1

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Buy BB-22 Powder Online, acts as a full agonist with a binding affinity of 0.217nM at CB1 and 0.338nM at CB2 cannabinoid receptors. BB-22 is a synthetic cannabinoid and an analog of JWH 018. This certified solution is suitable as starting material for calibrators or controls in synthetic cannabinoid GC/MS or LC/MS methods for urine drug testing, forensic analysis, or clinical toxicology applications. For those synthetic cannabinoids currently controlled at the federal level, our certified solution standards of these substances are DEA-exempt, allowing laboratories to place orders without additional regulatory paperwork. For US customers, state specific regulatory requirements may apply.

BB-22 is an analog of JWH 018 that is structurally similar to PB-22 (Item No. 14096) and its derivative, 5-fluoro PB-22 (Item No. 14095). Both BB-22 and PB-22 are distinctive in that an 8-hydroxyquinoline replaces the naphthalene group of JWH 018. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.

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What Is AM-2201?

AM-2201 is a synthetic cannabinoid, meaning it is a man-made compound that interacts with the endocannabinoid system by mimicking the effects of THC (tetrahydrocannabinol), the main psychoactive component in cannabis.

• Full chemical name (IUPAC): 1-(5-Fluoropentyl)-1H-indol-3-ylmethanone

• Other names: AM-2201, 5F-AM-2201 (due to the fluorinated chain)

• Chemical formula: C24H22FNO

• Molecular weight: ~375.44 g/mol

It was originally synthesized by a team led by Dr. Alexandros Makriyannis, hence the “AM” in its name, as part of research into cannabinoid receptor binding.

Buy AM-2201 crystal AM-2201 (1-(5-fluoropentyl)-3-(1-naphthoyl)indole) is a recreational designer drug that acts as a potent but nonselective full agonist for the cannabinoid receptor. It is part of the AM series of cannabinoids discovered by Alexandros Makriyannis at Northeastern University.
AM-2201 is a full agonist for cannabinoid receptors. Affinities are: with a Ki of 1.0 nM at CB1 and 2.6 nM at CB2. The 4-methyl functional analog MAM-2201 probably has similar affinities. AM-2201 has an EC50 of 38 nM for human CB1 receptors, and 58 nM for human CB2 receptors. AM-2201 produces bradycardia and hypothermia in rats at doses of 0.3–3 mg/kg, comparable to the potency of JWH-018 in rats, suggesting potent cannabinoid-like activity.

Product Description

AM2201 (Item No. 10707) is an analytical reference material characterized as a synthetic cannabinoid.

AM2201 is regulated as a Schedule I compound in the United States.

Abstract
Novel synthetic cannabinoids are appearing in recreational drug markets worldwide. Pharmacological characterization of these new drugs is needed to inform clinicians, toxicologists, and policy makers who monitor public health. [1-(5-Fluoropentyl)-1H-indol-3-yl](1-naphthyl)methanone (AM-2201) is an abused synthetic cannabinoid that was initially created as a research tool for investigating the endocannabinoid system.

Here we measured the pharmacodynamic effects of AM-2201 in rats, and simultaneously determined plasma pharmacokinetics for the parent drug and its metabolites. Male Sprague-Dawley rats were fitted with surgically implanted temperature transponders and indwelling jugular catheters under pentobarbital anesthesia. One week later, rats received subcutaneous injection of AM-2201 (0.1, 0.3, and 1.0 mg/kg) or its vehicle, and serial blood specimens were withdrawn via catheters. Core temperatures and catalepsy were measured just prior to each blood withdrawal, and plasma was assayed for drug and metabolites using liquid chromatography-tandem mass spectrometry.

Two new types of synthetic cannabinoids, an AM-2201 benzimidazole analog (FUBIMINA, 1) and (4-methylpiperazin-1-yl)(1-pentyl-1H-indol-3-yl)methanone (MEPIRAPIM, 2), and three newly emerged phenethylamine derivatives, 25B-NBOMe (3), 2C-N-NBOMe (4), and a 25H-NBOMe 3,4,5-trimethoxybenzyl analog (5), were detected in illegal products distributed in Japan.

The identification was based on liquid chromatography–mass spectrometry (LC–MS) and gas chromatography–mass spectrometry (GC–MS), high-resolution MS, and nuclear magnetic resonance analyses. Different from the representative synthetic cannabinoids, such as JWH-018, which have a naphthoylindole moiety, compounds 1 and 2 were completely new.

Chemical Structure and Properties

AM-2201 is structurally similar to other synthetic cannabinoids like JWH-018, but with a fluorine atom on the alkyl side chain. This modification increases the compound’s lipophilicity (fat solubility) and potentially its binding affinity to cannabinoid receptors.

Key Characteristics:

• High potency agonist at CB1 and CB2 receptors

• Lipophilic, allowing it to cross the blood-brain barrier efficiently

• Appears as a white to off-white powder in its pure form

• Often sprayed onto herbal plant material for recreational sale

Because of its structural similarity to other known synthetic cannabinoids, it is easy to confuse with other compounds unless verified through laboratory analysis.

Formal Name: [1-(5-fluoropentyl)-1H-indol-3-yl]-1-naphthalenyl-methanone
CAS Number: 335161-24-5
Molecular Formula: C24H22FNO
Formula Weight: 359.4
Purity: ?98%
Formulation: A neat solid
?max: 218, 247, 315 nm
SMILES: O=C(C1=CC=CC2=C1C=CC=C2)C3=CN(CCCCCF)C4=CC=CC=C43
InChi Code: InChI=1S/C24H22FNO/c25-15-6-1-7-16-26-17-22(20-12-4-5-14-23(20)26)24(27)21-13-8-10-18-9-2-3-11-19(18)21/h2-5,8-14,17H,1,6-7,15-16H2

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Storage: -20°C
Stability: ? 3 years

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Buy AB-PINACA Crystal online at our shop, it is a compound that was first identified as a component of synthetic cannabis products in Japan in 2012.

It was originally developed by Pfizer in 2009 as an analgesic medication.

AB-PINACA acts as a potent agonist for the CB1 receptor (Ki = 2.87 nM, EC50 = 1.2 nM) and CB2 receptor (Ki = 0.88 nM, EC50 = 2.5 nM) and fully substitutes for ?9-THC in rat discrimination studies, while being 1.5x more potent.

There have been a number of reported cases of deaths and hospitalizations in relation to this synthetic cannabinoid.

AB-PINACA is a synthetic cannabinoid usually sold as a herbal smoking mixture designed to mimic THC, the active chemical of cannabis. Synthetic cannabinoids are classed as ‘New Psychoactive Substances’ (NPS) which are unregulated substances that have become newly available on the market as an alternative to illegal drugs. As a reaction to prohibition, synthetic cannabinoid producers change the compounds found in designer drugs and create new generations of synthetic drugs, such as AB-PINACA. As a result, accidental overdose and severe psychiatric complications may be more likely to occur because the type and amount of active compound may vary considerably from batch to batch. Other effects may include agitation, rapid heart rate, confusion, dizziness and nausea.

AB-PINACA
A potent CB1 and CB2 receptor agonist, AB-PINACA is a member of the aminoalkylindazole class of synthetic cannabinoids. According to the NFLIS 2014 midyear report, AB-PINACA accounted for 11% of all synthetic cannabinoid drug reports in the United States during the first half of 2014. This certified reference solution is suited for use in synthetic cannabinoid testing methods by LC/MS or GC/MS for applications in clinical toxicology, urine drug testing, and forensic analysis.

*Statement on Forensic Use Products

Forensic Use Only devices are intended for use only in drugs of abuse testing for law enforcement purposes.

Appropriate users of such devices include, for example, court systems, police departments, probation/parole offices, juvenile detention centers, prisons, jails, correction centers and other similar law enforcement entities, or laboratories or other establishments performing forensic testing for these entities.

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Intended Use
The CEDIA® AB-PINACA assay is intended for the qualitative and semi-quantitative detection and estimation of the parent compound and metabolites of AB-PINACA, AB-CHMINACA, and AB-FUBINACA in human urine at a cutoff of 20 ng/mL. The assay is intended to be used in laboratories and provides a simple and rapid analytical screen to detect AB-PINACA-related synthetic cannabinoids compounds and metabolites in human urine. The semi-quantitative mode is for detection and for the purpose of enabling laboratories to determine an appropriate dilution of the specimen for confirmation by a confirmatory method such as Liquid chromatography/tandem mass spectrometry (LC-MS/MS) or permitting laboratories to establish quality control procedures. Clinical and professional judgment should be applied to any drug of abuse test result, particularly when preliminary positive results are used. For Criminal Justice and Forensic Use Only-Buy AB-PINACA Crystal Online.

Metabolite Analysis.

Twelve mice (n = 4 per drug) were given intraperitoneal injections of 3 mg/kg AB-PINACA, 3 mg/kg AB-CHMINACA, or 100 mg/kg FUBIMINA. Immediately following injections, the mice were placed into metabolism cages and urine was collected over a 24-hour period. Urine from mice dosed with the same compound was pooled for analysis. Samples were extracted using a salting-out liquid-liquid extraction method prior to analysis. Acetonitrile (200 µl) was added to 100 µL urine, and then the samples were vortexed and 50 µl 5 M ammonium acetate was added as a salting out agent. Samples were vortexed and centrifuged at 10,000 rcf for 5 minutes. The top aqueous layer was removed and dried down at 40°C and reconstituted with 50 µl mobile phase A.

Discussion
Psychoactive cannabinoid agonists produce a characteristic profile of in vitro and in vivo pharmacological effects, including binding to and activating CB1 receptors, dose-dependent activity in a tetrad battery of tests in mice, and ?9-THC–like discriminative stimulus effects (Wiley and Martin, 2009).

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What is AB-CHMINACA?

AB-CHMINACA is a synthetic cannabinoid chemically designed to activate the same receptors as THC (tetrahydrocannabinol), the active compound in natural cannabis. However, it interacts with those receptors much more strongly, leading to intense and sometimes dangerous effects.

• IUPAC name: N-[(1S)-1-(aminocarbonyl)-2-methylpropyl]-1-(cyclohexylmethyl)-1H-indazole-3-carboxamide

• Molecular formula: C20H28N4O2

• Molecular weight: ~356.46 g/mol

• Common form: Off-white to yellow crystalline powder

The compound belongs to the indazole-3-carboxamide family of synthetic cannabinoids, known for their strong activity at CB1 and CB2 receptors.

Chemical Structure and Classification

AB-CHMINACA contains:

• A cyclohexylmethyl group: increases lipophilicity (fat-solubility), helping the molecule pass through the blood-brain barrier.

• An indazole core: common in many synthetic cannabinoids.

• A valinate (amino acid-derived) side chain: this design enhances receptor binding.

Its structure is similar to that of other dangerous synthetic cannabinoids like AB-FUBINACA, which has been linked to mass overdoses.

Mechanism of Action

AB-CHMINACA acts as a full agonist at the CB1 and CB2 cannabinoid receptors:

• CB1 receptors are mainly located in the central nervous system and mediate most psychoactive effects.

• CB2 receptors are mostly found in the immune system and are linked to inflammatory responses.

Unlike THC, which is a partial agonist at these receptors, AB-CHMINACA binds more strongly and more completely, resulting in amplified effects and a greater risk of overdose.

Effects of CB1 receptor overstimulation:

• Euphoria and altered consciousness

• Panic, paranoia, hallucinations

• Heart rhythm disturbances

• Loss of motor control

Because of the full agonist activity and high potency, even very small doses of AB-CHMINACA can cause serious health effects.

Buy AB-CHMINACA crystal also 1-(cyclohexylmethyl)-1H-indazole-3- carboxamide. (AB-CHMINACA). is an indazole-based synthetic cannabinoid. It is a potent agonist of the CB1 receptor (Ki = 0.78 nM) and CB2 receptor (Ki = 0.45 nM) and fully substitutes for ?9-THC in rat discrimination studies, while being 16x more potent.

it contains a valine amino acid amide residue as part of its structure, where older cannabinoids contained a naphthyl or adamantane residue.

Formula:
C20H28N4O2

ChemSpider ID:
30646774

IUPAC name
N-[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]-1-(cyclohexylmethyl)indazole-3-carboxamide

An Analytical Reference Standard
Item No.
28236

Purity:
?98%

Formulation:
A crystalline solid
ADB-CHMINACA (MAB-CHMINACA)
is a new synthetic cannabinoid with high potency and many reported adverse events and fatalities. The drug is currently scheduled in several countries in Europe and the USA.

Analyse
Analyse method developed to confirm ADB-CHMINACA intake for clinical and forensic programs. For many synthetic cannabinoids, parent compound is not detectable in biological samples after intake, making the detection of metabolites the only way to prove consumption. Therefore, detection of ADB-CHMINACA metabolites in biological specimens is critical.

Part Description
LP262538-4 AB-CHMINACA butanoate
AB-CHMINACA hydroxycyclohexyl and AB-CHMINACA butanoate are metabolites of AB-CHMINACA (N-[1-amino-3-methyl-oxobutan-2-yl]-1-[cyclohexylmethyl]-1H-indazole-3-carboxamide), an indazole-based synthetic cannabinoid that shows high affinity for cannabinoid CB1 and CB2 receptors.

Synthetic cannabinoids interact with the same brain receptors as THC (the active drug present in marijuana) and have been demonstrated to produce similar effects. The drug is typically sprayed on botanical material and smoked, although it can be ingested in liquid or also powder form. Products containing this drug are sold under a wide variety of names including (but not limited to) Spice, Potpourri, Smoke, K2, Zombie, Kush, and Cloud 10.

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5F-UR-144, also written as 5FUR-144, is a synthetic cannabinoid that has appeared in the designer drug market as part of a wave of “legal highs” sold under names like Spice, K2, or herbal incense. These substances are typically designed to mimic the effects of THC, the psychoactive ingredient in cannabis, while avoiding detection and regulation—at least initially.

5F-UR-144 is chemically similar to other synthetic cannabinoids like UR-144 and XLR-11, but features a fluorinated side chain, which increases potency and alters how the compound interacts with cannabinoid receptors. While it was initially developed for potential medical or scientific research, it has gained notoriety for its unpredictable effects and potential for serious harm.

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5F-UR-144 is a synthetic compound that acts as an agonist at cannabinoid receptors in the body, primarily CB1 and CB2 receptors. It is part of the tetramethylcyclopropyl synthetic cannabinoid family, which includes several structurally similar compounds.

• IUPAC Name: 1-(5-Fluoropentyl)-1H-indol-3-yl-methanone

• Chemical formula: C21H29FN2O

• Molecular weight: ~344.5 g/mol

• Common form: White or off-white powder, often dissolved and sprayed on herbal material

The name 5F-UR-144 indicates that it is a fluorinated analog of UR-144, with a fluorine atom attached to the terminal carbon of the pentyl side chain. This small change significantly affects its pharmacological properties, often increasing potency.

Chemical Structure and Classification

Key Features:

• Indole core: Common in many synthetic cannabinoids.

• 5-Fluoropentyl side chain: Enhances receptor binding.

• Tetramethylcyclopropyl group: A bulky, hydrophobic group that may affect metabolism and receptor affinity.

5F-UR-144 is categorized as:

• A synthetic cannabinoid receptor agonist (SCRA)

• Structurally similar to UR-144, XLR-11, and 5F-PB-22

• Often found in “herbal smoking blends” or e-liquids for vaporization

Buy 5FUR-144 Powder XLR-11 (5?-fluoro-UR-144) is a drug that acts as a potent agonist for the cannabinoid receptors CB1 and CB2 with EC50 values of 98 nM and 83 nM, respectively.

It is a 3-(tetramethylcyclopropylmethanoyl)indole derivative related to compounds such as UR-144, A-796,260 and A-834,735, but it is not specifically listed in the patent or scientific literature alongside these other similar compounds, and appears to have not previously been made by Abbott Laboratories, despite falling within the claims of patent WO 2006/069196. XLR-11 was found to produce rapid, short-lived hypothermic effects in rats at doses of 3 mg/kg and 10 mg/kg, suggesting that it is of comparable potency to APICA and STS-135.

Detection
A forensic standard for this compound is available, and a representative mass spectrum has been posted on Forendex.

Side effects
XLR-11 has been linked to hospitalizations due to its use.

Recreational use
XLR-11 was instead first identified by laboratories in 2012 as an ingredient in synthetic cannabis smoking blends, and appears to be a novel compound invented specifically for grey-market recreational use.

Chemical and physical data
Formula: C21H28FNO

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Chemical Background

5F-UR-144 belongs to the UR-144 family of synthetic cannabinoids. Its chemical name includes “5F,” indicating the presence of a fluorine atom at the 5th position of the pentyl chain. The fluorination is common in synthetic cannabinoids because it can enhance the compound’s potency and influence its pharmacokinetics.

The molecular structure of 5F-UR-144 includes:

• An indole core, which is typical in many synthetic cannabinoids

• A pentyl chain modified with a fluorine atom (hence the “5F”)

• A carboxamide linker

This structure binds primarily to cannabinoid receptors CB1 and CB2 in the human body, mimicking natural cannabinoids like THC.

Buy 5fur-144 Crystal (XLR-11 or 5?-fluoro-UR-144) is a drug that acts as a potent agonist for the cannabinoid receptors CB1 and CB2 with EC50 values of 98 nM and 83 nM, respectively.

It is a 3-(tetramethylcyclopropylmethanoyl)indole derivative related to compounds such as UR-144, A-796,260 and A-834,735, but it is not specifically listed in the patent or scientific literature alongside these other similar compounds, and appears to have not previously been made by Abbott Laboratories, despite falling within the claims of patent WO 2006/069196. XLR-11 was found to produce rapid, short-lived hypothermic effects in rats at doses of 3 mg/kg and 10 mg/kg, suggesting that it is of comparable potency to APICA and STS-135.

Chemical and physical data

Formula: C21H28FNO

Molar mass: 329.459 g·mol?1

Detection
A forensic standard for this compound is available, and a representative mass spectrum has been posted on Forendex

Side effects
XLR-11 has been linked to hospitalizations due to its use

Toxicity
XLR-11 has been linked to acute kidney injury in some users, along with AM-2201.

Legal Status
XLR-11 was banned in New Zealand by being added to the temporary class drug schedule, effective from 13 July 2012.

The U.S. Drug Enforcement Administration (DEA) made the synthetic cannabinoids UR-144, XLR11, and AKB48 Schedule I, illegal drugs under the Controlled Substances Act (CSA) for the next two years as of 16 May 2013.

It has also been banned in Florida as of December 11, 2012.

Arizona banned XLR-11 on 3 April 2013.

As of October 2015 XLR-11 is a controlled substance in China.

XLR-11 is banned in the Czech Republic

Mechanism of Action

5F-UR-144 acts as an agonist at cannabinoid receptors, mainly CB1 receptors found in the central nervous system and CB2 receptors located primarily in the immune system. By binding to these receptors, it activates intracellular signaling pathways similar to THC, the primary psychoactive component of cannabis.

CB1 receptor activation leads to altered neurotransmitter release, affecting mood, memory, pain perception, and motor control. CB2 receptor activation generally modulates inflammation and immune responses.

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Buy 5F-PB22 Crystal is a designer drug which acts as a cannabinoid agonist. The structure of 5F-PB-22 appears to have been designed with an understanding of structure–activity relationships within the indole class of cannabinoids.

5-fluoro PB-22 (Item No. 14095) is an analytical reference material that is structurally categorized as a synthetic cannabinoid (CB). It is a full agonist of human CB1 and CB2 receptors (pEC50s = 8.55 and 7.97, respectively).1,2 5-fluoro PB-22 potently and dose-dependently induces hypothermia and reduces heart rate in rats, mimicking the in vivo effects of ?9-THC (Item Nos. 12068 | ISO60157).1 This product is intended for research and forensic applications.

5F-PB22 is a synthetic cannabinoid, a chemical designed to mimic the effects of cannabinoids found naturally in the cannabis plant. Synthetic cannabinoids have gained attention due to their use in recreational drug markets and their potential applications in scientific research. However, they also pose significant risks because of their potency, unpredictable effects, and sometimes unknown toxicology.

This overview will cover the chemical nature, pharmacology, effects, risks, and legal status of 5F-PB22 to provide a comprehensive understanding suitable for educational purposes.

Chemical Nature and Structure

5F-PB22 is chemically known as quinolin-8-yl 1-(5-fluoropentyl)-1H-indole-3-carboxylate. It belongs to the broader class of indole-based synthetic cannabinoids, which are characterized by an indole core structure connected to various side chains and functional groups.

The “5F” in its name indicates the presence of a fluorine atom attached to the fifth carbon of the pentyl side chain, a common modification in synthetic cannabinoids that often enhances potency and alters metabolic stability.

The molecular structure can be broken down as follows:

• Indole core: A bicyclic structure composed of a benzene ring fused to a pyrrole ring.

• Carboxylate ester linkage: Connecting the indole core to a quinoline ring (quinolin-8-yl group).

• 5-fluoropentyl side chain: A pentyl chain with a fluorine atom at the terminal end, influencing receptor affinity.

This structure allows 5F-PB22 to interact with cannabinoid receptors in the human body.

Pharmacology
5F-PB-22 acts as a full agonist with a binding affinity of 0.468 nM at CB1 and 0.633 nM at CB2cannabinoid receptors.

Chemical and physical data
Formula: C23H21FN2O2

Molar mass: 376.431 g·mol?1

Technical Information

Formal Name1-(5-fluoropentyl)-8-quinolinyl ester-1H-indole-3-carboxylic acid
CAS Number1400742-41-7
Molecular FormulaC23H21FN2O2
Formula Weight376.4
Purity?98%
FormulationA neat solid
SMILESO=C(OC1=C(N=CC=C2)C2=CC=C1)C3=CN(CCCCCF)C4=C3C=CC=C4
InChi CodeInChI=1S/C23H21FN2O2/c24-13-4-1-5-15-26-16-19(18-10-2-3-11-20(18)26)23(27)28-21-12-6-8-17-9-7-14-25-22(17)21/h2-3,6-12,14,16H,1,4-5,13,15H2
InChi KeyMBOCMBFDYVSGLJ-UHFFFAOYSA-N
WARNING This product is not for human or veterinary use.

Shipping & Storage Information
Storage: -20°C
Shipping: Room Temperature in continental US; may vary elsewhere
Stability: ? 3 years

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5F-MMB-PICA is a synthetic cannabinoid, part of a class of designer drugs created to mimic the effects of THC, the psychoactive compound found in cannabis. These compounds interact with the body’s cannabinoid receptors but often with much higher potency and unpredictable effects. 5F-MMB-PICA has been found in some recreational synthetic cannabinoid products and is of interest both scientifically and from a public health perspective.

This overview covers the chemical nature, pharmacology, effects, risks, and legal considerations of 5F-MMB-PICA.

 synthetic cannabinoid also known as 5F-MMB-PICA, 5F-AMB-PICA, and I-AMB.

Chemical Structure and Nature

5F-MMB-PICA is part of the indole-3-carboxamide family of synthetic cannabinoids. Its full chemical name is methyl (2S)-2-[[1-(5-fluoropentyl)indole-3-carbonyl]amino]-3,3-dimethylbutanoate.

Key features of 5F-MMB-PICA’s structure include:

• Indole core: A bicyclic ring system typical in many synthetic cannabinoids.

• 5-fluoropentyl side chain: A five-carbon chain with a fluorine atom at the terminal position, which often increases binding affinity to cannabinoid receptors.

• MMB group: This refers to a methyl ester moiety attached to the carboxamide group.

This combination creates a molecule that can strongly bind to cannabinoid receptors in the body.

Mechanism of Action

5F-MMB-PICA acts as a full agonist at both CB1 and CB2 cannabinoid receptors.

• CB1 receptors, mainly found in the brain and central nervous system, mediate psychoactive effects such as altered mood, perception, and cognition.

• CB2 receptors, located mostly in peripheral tissues and immune cells, are involved in regulating inflammation and immune response.

Because 5F-MMB-PICA is a full agonist with high affinity, it can produce much stronger and more intense effects than THC, which is only a partial agonist.

Synonyms MDMB-2201 5-fluoro-MDMB-2201

CAS Number 1971007-88-1
Molecular Formula C21H29FN2O3
Formula Weight 376.5
Purity ?100%
Formulation A crystalline solid ?max 217, 290 nm
Control Status 5f mdmb 2201
5F-MDMB-PICA is a Schedule I controlled substance under the Federal Controlled Substances Act.

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The National Forensic Laboratory Information System (NFLIS), a system that collects drug analysis information from state and local forensic laboratories, contain 340 reports for 5F-MDMB-PICA between 2016 and 2018.

Storage Information
Storage: -20°C
Shipping : Room Temperature in continental US; may vary elsewhere
Stability: ? 2 years
Pharmacology:
Data from preclinical studies show that 5F-MDMBPICA binds to and acts as an agonist at the CB1 receptor. There are no published studies on the safety of 5FMDMB-PICA for human use.

MMB-2201 is the indole core analogue of 5F-AMB. Synthetic cannabinoid compounds with an indole-3-carboxamide or indazole-3-carboxamide core bearing a N-1-methoxycarbonyl group with attached isopropyl or tert-butyl substituent, have proved to be much more dangerous than older synthetic cannabinoid compounds previously reported, and have been linked to many deaths in Russia, Japan, Europe and the United States.

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What  is 5F-QUPIC

5F-BB-22, also known as 5F-QUPIC, is a synthetic cannabinoid a type of lab-made chemical designed to mimic the effects of THC, the main psychoactive compound found in cannabis. It belongs to the indole-based class of synthetic cannabinoids and is structurally similar to BB-22, with a fluorine atom attached to its pentyl chain (hence the “5F” prefix).

These compounds were initially synthesized for research purposes, specifically to study the endocannabinoid system. However, many synthetic cannabinoids, including 5F-BB-22, found their way into the recreational drug market and have been sold under misleading names such as “herbal incense,” “Spice,” or “K2.”

Buy 5F-BB22 Crystal is an analytical reference material that is structurally categorized as a synthetic cannabinoid (CB). It is a full agonist of human CB1 and CB2 receptors (pEC50s = 8.55 and 7.97, respectively).1,2 5-fluoro PB-22 potently and dose-dependently induces hypothermia and reduces heart rate in rats, mimicking the in vivo effects of ?9-THC.1 This product is intended for research and forensic applications.

Pharmacology

5F-BB22 acts as a full agonist with a binding affinity of 1.94 nM at CB1 and 0.266 nM at CB2 cannabinoid receptors.

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Although they are synthetic, our cannabinoids have a close affinity with natural compounds that occur in the cannabis plant. Not only do they release their effects in the same way (by interacting with cannabinoid receptors), but they are also associated with high selectivity and little to no toxicity. Besides, our cannabinoids are proven to trigger the same nervous system responses, which is especially important for research in the area.

Chemical Structure and Classification

• Full name: 1-(5-Fluoropentyl)-1H-indole-3-carboxylic acid [1-(quinuclidin-3-yl) methyl] ester

• Chemical Class: Synthetic cannabinoid (Indole-based)

• Molecular Formula: C25H31FN2O2

5F-BB-22 acts as a full agonist at the CB1 and CB2 receptors in the body’s endocannabinoid system, which regulates mood, appetite, pain sensation, and memory. Compared to natural THC, which is a partial agonist, compounds like 5F-BB-22 often produce much stronger and more unpredictable effects.

Mechanism of Action

5F-BB-22 binds strongly to cannabinoid receptors (especially CB1, located primarily in the brain), leading to powerful psychoactive effects. Due to its full agonist nature, the effects can be significantly more intense than natural cannabis, often resulting in harmful outcomes such as:

• Extreme anxiety

• Hallucinations

• Elevated heart rate

• Loss of consciousness

• Seizures

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Buy 5F-AKB48 Powder (also known as 5F-AKB-48 or 5F-APINACA) is an indazole-based synthetic cannabinoid that has been sold online as a designer drug. Structurally it closely resembles cannabinoid compounds from patent WO 2003/035005 but with a 5-fluoropentyl chain on the indazole 1-position, and 5F-APINACA falls within the claims of this patent, as despite not being disclosed as an example, it is very similar to the corresponding pentanenitrile and 4-chlorobutyl compounds which are claimed as examples 3 and 4. In the United States, 5F-AKB48 is a Schedule I controlled substance.

5F-AKB48 is an Anlage II controlled drug in Germany since July 2013. As of October 2015, 5F-AKB48 is a controlled substance in China.

5F-AKB48 is banned in the Czech Republic.

Chemical Information

• Full Name: N-(1-Adamantyl)-1-(5-fluoropentyl)-1H-indazole-3-carboxamide

• Common Name(s): 5F-AKB48, 5F-APINACA

• Chemical Class: Synthetic cannabinoid (indazole-carboxamide)

• Molecular Formula: C23H31FN4O

• Structure Feature: Fluoropentyl chain on the indazole core, with an adamantyl group for increased receptor binding.

5F-AKB48 was first identified in South Korea. It is expected to be a potent agonist of the CB1 receptor and CB2 receptor. Its metabolism has been described in literature.

Chemical and physical data
Formula: C23H30FN3O

Molar mass: 383.5 g/mol g·mol?1

Pharmacology
5F-AKB48 acts as a full agonist with a binding affinity of 1.94 nM at CB1 and 0.266 nM at CB2 cannabinoid receptors.

How It Works (Mechanism of Action)

5F-AKB48 acts as a full agonist at the CB1 and CB2 receptors, which are part of the endocannabinoid system that regulates mood, memory, appetite, pain sensation, and motor control.

• CB1 receptors are located mainly in the brain and central nervous system.

• CB2 receptors are primarily found in the immune system and peripheral tissues.

Unlike THC (a partial agonist), 5F-AKB48 binds more strongly and activates these receptors more fully, making it far more potent and dangerous.

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Mercury powder refers to finely divided elemental mercury or mercury compounds in powdered form. While mercury is most commonly encountered as a liquid metal at room temperature, it can also exist in solid powdered forms, either as metal particles or as chemical compounds such as mercuric oxide (HgO) or mercuric sulfide (HgS).

Though mercury has historical and industrial uses, powdered mercury and its compounds are toxic and pose serious health and environmental hazards. Understanding what mercury powder is, how it is used, and the dangers associated with it is crucial for safety and education.

BUY MERCURY POWDER Mercury is a chemical element with the symbol Hg and atomic number 80. A heavy, silvery d-block element, mercury is the only metallic element that is liquid at standard conditions for temperature and pressure; the only other element that is liquid under these conditions is the halogen bromine, though metals such as caesium, gallium, and rubidium melt just above room temperature. Established in the year 2011, Parshwamani Metals is a distinguished manufacturer, supplier and trader offering an enormous consignment of Industrial Metal Tube, Beryllium Product, Shim Sheet, SS Round And Square Bar, Aluminium Products, Aluminum Bronze Products etc. Besides these, we also provide products such as, Hollow Brass Tube, Brass Tube, Refrigeration Copper Tube, Beryllium Copper Plates, Stainless Steel Shim Sheet, SS Square Bar, Aluminium Chequered Plates, Nickel Aluminum Bronze etc. Mercury occurs in deposits throughout the world mostly as cinnabar (mercuric sulfide).

It remains in use in scientific research applications and in amalgam for dental restoration in some locales. It is also used in fluorescent lighting. Electricity passed through mercury vapor in a fluorescent lamp produces short-wave ultraviolet light, which then causes the phosphor in the tube to fluoresce, making visible light. Mercury poisoning can result from exposure to water-soluble forms of mercury (such as mercuric chloride or methylmercury), by inhalation of mercury vapor, or by ingesting any form of mercury.BUY MERCURY POWDER Europe , MERCURY for sale online Germany , Where to buy research Chemical France, Purchase MERCURY Online Vendor

Chemical properties
Mercury does not react with most acids, such as dilute sulfuric acid, although oxidizing acids such as concentrated sulfuric acid and nitric acid or aqua regia dissolve it to give sulfate, nitrate, and chloride. Like silver, mercury reacts with atmospheric hydrogen sulfide. Mercury reacts with solid sulfur flakes, which are used in mercury spill kits to absorb mercury (spill kits also use activated carbon and powdered zinc).

Specification:
MF: C
Other Names: Activated Charcoal
Purity: 99.9%
Type: Adsorbent
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Adsorbent Variety: Activated Carbon
Physical properties
A complete explanation of mercury’s extreme volatility delves deep into the realm of quantum physics, but it can be summarized as follows: mercury has a unique electron configuration where electrons fill up all the available 1s, 2s, 2p, 3s, 3p, 3d, 4s, 4p, 4d, 4f, 5s, 5p, 5d, and 6s subshells. Because this configuration strongly resists removal of an electron, mercury behaves similarly to noble gases, which form weak bonds and hence melt at low temperatures.

The stability of the 6s shell is due to the presence of a filled 4f shell. An f shell poorly screens the nuclear charge that increases the attractive Coulomb interaction of the 6s shell and the nucleus (see lanthanide contraction). The absence of a filled inner f shell is the reason for the somewhat higher melting temperature of cadmium and zinc, although both these metals still melt easily and, in addition, have unusually low boiling points.BUY MERCURY POWDER Europe

Occupational exposure
EPA workers clean up residential mercury spill in 2004
Due to the health effects of mercury exposure, industrial and commercial uses are regulated in many countries. The World Health Organization, OSHA, and NIOSH all treat mercury as an occupational hazard, and have established specific occupational exposure limits. Environmental releases and disposal of mercury are regulated in the U.S. primarily by the United States Environmental Protection Agency.

Applications
It is used primarily for the manufacture of industrial chemicals or for electrical and electronic applications. It is used in some thermometers, especially ones which are used to measure high temperatures. A still increasing amount is used as gaseous mercury in fluorescent lamps, while most of the other applications are slowly phased out due to health and safety regulations and is in some applications replaced with less toxic but considerably more expensive Galinstan alloy.

Production of chlorine and caustic soda
Chlorine is produced from sodium chloride (common salt, NaCl) using electrolysis to separate the metallic sodium from the chlorine gas. Usually the salt is dissolved in water to produce a brine. By-products of any such chloralkali process are hydrogen (H2) and sodium hydroxide (NaOH), which is commonly called caustic soda or lye. By far the largest use of mercury in the late 20th century was in the mercury cell process (also called the Castner-Kellner process) where metallic sodium is formed as an amalgam at a cathode made from mercury; this sodium is then reacted with water to produce sodium hydroxide. Many of the industrial mercury releases of the 20th century came from this process, although modern plants claimed to be safe in this regard. After about 1985, all new chloralkali production facilities that were built in the United States used membrane cell or diaphragm cell technologies to produce chlorine.

Treatment
Research on the treatment of mercury poisoning is limited. Currently available drugs for acute mercurial poisoning include chelators N-acetyl-D, L-penicillamine (NAP), British Anti-Lewisite (BAL), 2,3-dimercapto-1-propanesulfonic acid (DMPS), and dimercaptosuccinic acid (DMSA). In one small study including 11 construction workers exposed to elemental mercury, patients were treated with DMSA and NAP. Chelation therapy with both drugs resulted in the mobilization of a small fraction of the total estimated body mercury. DMSA was able to increase the excretion of mercury to a greater extent than NAP.

See also
Amalgam (dentistry)
Mercury poisoning
Mercury pollution in the ocean
Methylmercury
Minamata disease
Red mercury
COLEX process (isotopic separation)
Medicine
Buy mercury powder and its compounds have been used in medicine, although they are much less common today than they once were, now that the toxic effects of mercury and its compounds are more widely understood. It is an ingredient in dental amalgams. Thiomersal (called Thimerosal in the United States) is an organic compound used as a preservative in vaccines, though this use is in decline. Thiomersal is metabolized to ethyl mercury. Although it was widely speculated that this mercury-based preservative could cause or trigger autism in children, scientific studies showed no evidence supporting any such link. Nevertheless, thiomersal has been removed from, or reduced to trace amounts in all U.S. vaccines recommended for children 6 years of age and under, with the exception of inactivated influenza vaccine.

Another mercury compound, merbromin (Mercurochrome), is a topical antiseptic used for minor cuts and scrapes that is still in use in some countries.

Buy mercury powder online,  in the form of one of its common ores, cinnabar, is used in various traditional medicines, especially in traditional Chinese medicine. Review of its safety has found that cinnabar can lead to significant mercury intoxication when heated, consumed in overdose, or taken long term, and can have adverse effects at therapeutic doses, though effects from therapeutic doses are typically reversible. Although this form of mercury appears to be less toxic than other forms, its use in traditional Chinese medicine has not yet been justified, as the therapeutic basis for the use of cinnabar is not clear